Buy rydapt

Rydapt (midostaurin)

$26,750.00 $22,900.00

How to buy Rydapt (midostaurin): You can order Rydapt (midostaurin) from #Cancerdrugs247 if the drug has not been approved or is not available in your country. 

Oncology Leukemia
Marketing Authorisation Holder Novartis Europharm Limited
Mode of Action Kinase inhibitor (chemotherapy)
Administration Oral
Regulatory agency approval European Medical Agency (EMA), European Union, Food and Drug Administration (FDA), USA
Strength 25 milligram
Package 112 Capsules


SKU: RYDAPT Category: Tags: ,


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Important Information

What is Rydapt (midostaurin) used for? 

Rydapt (midostaurin) is indicated for the treatment of patients with1,3:

  • Newly diagnosed acute myeloid leukemia (AML) that is FLT3 mutation positive as detected by an FDA-approved test, in combination with chemotherapy (standard cytarabine and daunorubicin induction and cytarabine consolidation). Rydapt (midostaurin)is not indicated as a single-agent induction therapy for the treatment of patients with AML.

  • Aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL).

How does Rydapt (midostaurin) work?

The active substance in Rydapt is midostaurin, a kinase inhibitor that works by blocking several enzymes that promote cell growth2,4.

Midostaurin demonstrated the ability to inhibit FLT3 receptor signalling and cell proliferation, and it induced apoptosis in leukemic cells expressing ITD and TKD mutant FLT3 receptors or overexpressing wild type FLT3 and PDGF receptors. Midostaurin also demonstrated the ability to inhibit KIT signalling, cell proliferation, and histamine release and induce apoptosis in mast cells1,4.

Is Rydapt (midostaurin) approved?

Rydapt (midostaurin) was approved for patients newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3, in combination with chemotherapy; and for patients with systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL)1,3 by:

  • Food and Drug Administration (FDA) (USA) on April 28, 2017
  • European Medicines Agency (EMA) (EU) on October 25, 2017

How do I take Rydapt (midostaurin)?

The standard dosage for AML is:

  • 50 mg (2 capsules) orally twice daily with food.

The standard dosage for ASM, SM-AHN, and MCL is:

  • 100 mg (4 capsules) orally twice daily with food.

Complete information about Rydapt (midostaurin) dosage and administration can be found in the resources section. 

Note: Consult your treating doctor for personalised dosing.

Are there any known side effects of Rydapt (midostaurin)?

Among the common side effects in patients with AML are low levels of white blood cells with fever (febrile neutropenia), nausea and inflammation of the mucous membranes (mucositis)1.

Among the patients with ASM, SM-AHN, or MCL the most common adverse reactions (≥ 20%) were nausea, vomiting, diarrhea, edema, musculoskeletal and abdominal pain1.

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information1.

Follow the following prescription medicine precautions :

    Rydapt may be harmful in pregnancy and there is a potential risk of miscarriage or carrying a child with birth defects if you or your partner becomes pregnant during this time. Take proper medical help in case you are pregnant, may be pregnant or planning to become pregnant in the near future.
  This medicine is not indicated for use in women. It is not known if  Rydapt is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Rydapt, a decision should be made to either discontinue nursing, or discontinue the drug taking into account the importance of the drug to the mother.
  Your health care professional may recommend blood tests to see how your body is working. Blood tests help doctors check for certain diseases and conditions. They also help check the function of your organs and show how well treatments are working.
  Before taking Rydapt, tell your doctor and pharmacist if you are allergic to  Rydapt, any other medications, or any of the ingredients in Rydapt injection. This medicine is not recommended for use in patients with a known allergy to Rydapt.
  If you take Rydapt, you must stop drinking alcohol. This is one of the ways to prevent this disease from getting worse. If you are dependent on alcohol and want to stop drinking, your doctor can recommend a therapy that’s tailored for your needs.
  If you use other prescription drugs or over the counter products at the same time, the effects of Rydapt may change. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that your pharmacist can help you prevent or manage drug interactions.
  Missing a dose of Rydapt can upset your treatment plan. If you do miss one of your doses, take it as soon as you remember, unless it’s almost time to take your next dose. In this case, you should just skip the missed dose. Don’t take a double dose to “make up” for the one you missed. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
  Do not take Rydapt the use by (expiry) date printed on the pack. Do not take it if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.
  During your treatment with Rydapt, it is very important for your doctor to know about your medical history if you have Kidney problems, liver problems, HIV, triglycerides, diabetes or other health problems.


What are the storage instructions for Rydapt ?

Patients must properly store the drug to retain its quality and efficacy. Following storage instructions will be helpful in storing the drug in the best of manner. 

  • Store Rydapt at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).
  • Store it in a cool, dry place, protected from light and refrigerated when necessary. Improper storage can affect the effectiveness and shelf life of your medicine.
  • Consider storing your medications separately from your other family members. You can put them on a different shelf, or in a different cabinet or drawer.
  • If you’re driving, you may want to have certain medicines at hand, but don’t store them in the glove compartment, where they could be damaged from the heat, cold, or rain outside or from the car’s heater or air conditioner.
  • Always remember to store your medication out of sight and reach of children and pets, to prevent accidental ingestion.

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In order to legally purchase this medicine from , you’ll require a prescription from your Registered Medical Practitioner.


The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.


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