Buy Rubraca (rucaparib) From Cancerdrugs247.com
What is Rubraca (rucaparib) for?
Rubraca (rucaparib) is indicated as monotherapy for:
the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer, who have been treated with two or more chemotherapies1. Patients should be selected for therapy based on the FDA-approved FoundationFocus CDxBRCA test (Foundation Medicine Inc.)2,1. Approximately 15 to 20% of patients with ovarian cancer have a BRCA gene mutation3.
for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy1.
How does Rubraca (rucaparib) work?
BRCA genes are involved with repairing damaged DNA and normally work to prevent tumour development. However, mutations of these genes may lead to certain cancers, including ovarian cancers. Rubraca (rucaparib) is a poly ADP-ribose polymerase (PARP) inhibitor that blocks an enzyme involved in repairing damaged DNA. By blocking this enzyme, DNA inside the cancerous cells with damaged BRCA genes may be less likely to be repaired, leading to cell death and possibly a slowdown or stoppage of tumour growth3.
Where has Rubraca (rucaparib) been approved?
Rubraca (rucaparib) was approved by:
- Food and Drug Administration (FDA), USA:
- on December 19, 2016, for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies1
- on April 6, 2018, for the for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy1.
How is Rubraca (rucaparib) taken?
The standard dosage is:
- 600 mg orally twice daily.
Patients should be monitored for hematologic toxicity at baseline and monthly thereafter, and use of Rubraca (rucaparib) should be discontinued if myelodysplastic syndrome (MDS) / acute myeloid leukemia (AML) is confirmed1.
Complete information about Rubraca (rucaparib) dosage and administration can be found in the resources section.
Note: Consult your treating doctor for personalised dosing.
Are there any known side effects or adverse reactions of Rubraca (rucaparib)?
Common adverse reactions
The most common adverse reactions listed in the prescribing information include:
- abdominal pain
- dysgeusia (distortion of the sense of taste)
- decreased appetite
- thrombocytopenia (deficiency of platelets in the blood)
- dyspnea (difficult breathing)1.
Serious adverse reactions
The serious adverse reactions listed in the prescribing information include:
- myelodysplastic syndrome/acute myeloid leukemia (MDS/AML).
Use in specific populations
Rubraca (rucaparib) can be fatal for a fetus, it is advised to avoid pregnancies and breast feeding.
Follow the following prescription medicine precautions :
|Rubraca may be harmful in pregnancy and there is a potential risk of miscarriage or carrying a child with birth defects if you or your partner becomes pregnant during this time. Take proper medical help in case you are pregnant, may be pregnant or planning to become pregnant in the near future.|
|This medicine is not indicated for use in women. It is not known if Rubraca is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Rubraca, a decision should be made to either discontinue nursing, or discontinue the drug taking into account the importance of the drug to the mother.|
|Your health care professional may recommend blood tests to see how your body is working. Blood tests help doctors check for certain diseases and conditions. They also help check the function of your organs and show how well treatments are working.|
|Before taking Rubraca, tell your doctor and pharmacist if you are allergic to Rubraca, any other medications, or any of the ingredients in Rubraca injection. This medicine is not recommended for use in patients with a known allergy to Rubraca.|
|If you take Rubraca, you must stop drinking alcohol. This is one of the ways to prevent this disease from getting worse. If you are dependent on alcohol and want to stop drinking, your doctor can recommend a therapy that’s tailored for your needs.|
|If you use other prescription drugs or over the counter products at the same time, the effects of Rubraca may change. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that your pharmacist can help you prevent or manage drug interactions.|
|Missing a dose of Rubraca can upset your treatment plan. If you do miss one of your doses, take it as soon as you remember, unless it’s almost time to take your next dose. In this case, you should just skip the missed dose. Don’t take a double dose to “make up” for the one you missed. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.|
|Do not take Rubraca the use by (expiry) date printed on the pack. Do not take it if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.|
|During your treatment with Rubraca, it is very important for your doctor to know about your medical history if you have Kidney problems, liver problems, HIV, triglycerides, diabetes or other health problems.|
What are the storage instructions for Rubraca ?
Patients must properly store the drug to retain its quality and efficacy. Following storage instructions will be helpful in storing the drug in the best of manner.
- Store Rubraca at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).
- Store it in a cool, dry place, protected from light and refrigerated when necessary. Improper storage can affect the effectiveness and shelf life of your medicine.
- Consider storing your medications separately from your other family members. You can put them on a different shelf, or in a different cabinet or drawer.
- If you’re driving, you may want to have certain medicines at hand, but don’t store them in the glove compartment, where they could be damaged from the heat, cold, or rain outside or from the car’s heater or air conditioner.
- Always remember to store your medication out of sight and reach of children and pets, to prevent accidental ingestion.
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The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.